Is pauwels classification still validating
In contrast, in the chemotherapy group, no significant change from baseline in global quality of life was observed at any time validate.
S1 in the Supplementary Appendix. The prespecified number of progression events or deaths was reached in March ; the date of data cutoff was March 30, In conclusion, this study showed that crizotinib, as compared with chemotherapy, prolonged progression-free survival, increased response rates, and improved the quality of life in patients with advanced, previously treated ALK-positive non—small-cell lung cancer.
Second, significantly more patients in the crizotinib group continued treatment beyond RECIST-defined progression of disease, and the duration of such therapy was longer with crizotinib than with chemotherapy. The time to deterioration was calculated as the time from randomization que significa subjetivo yahoo dating the first increase of 10 points or more indicating worsening condition from baseline in scores for a composite end point of chest pain, dyspnea, or cough.
Progression-free survival was defined as the time from randomization to progression of the disease, as assessed by means of independent radiologic review, or to death.
For symptoms, higher scores indicate greater severity of symptoms; for global quality of life, higher scores indicate better global quality of life. The P values which have not been adjusted for classification still testing are for the between-group comparison of the overall change from baseline, as calculated with the use of repeated-measure analyses.
S4 in the Supplementary Appendix. In the intention-to-treat population, the response rate, as verified by means of independent radiologic review, was significantly higher in the crizotinib group than in the chemotherapy group: All patients provided written informed consent.
We thank the participating patients and their families; the network of investigators listed in the Supplementary Appendixavailable at NEJM. In the as-treated population, the response rate was higher with crizotinib than with either type of chemotherapy Fig.
Panel A shows the overall change from baseline in the symptoms of alopecia, cough, dyspnea, fatigue, chest pain, arm or shoulder pain, and pain in other parts of the body, as well as in global quality-of-life QOL scores.
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